Diabetes is related with a number of cystopathic
complications. However, there have been no studies about the influence of
alcohol consumption in the
bladder of
type 2 diabetes. Thus, we investigated the effect of moderate
alcohol intake in the
bladder of the Otsuka Long Evans Tokushima Fatty (OLETF) diabetic
rat. The non-diabetic Long-Evans Tokushima Otsuka (LETO, n=14) and the OLETF
control group (n=14) were fed an isocaloric
diet; the LETO (n=14) and the OLETF
ethanol group (n=14) were fed 36%
ethanol 7 g/kg/day. After ten weeks,
muscarinic receptors, RhoGEFs, myogenic change, and the level of
oxidative stress were evaluated. Moderate
alcohol intake significantly decreased excessive
muscarinic receptor and
Rho kinase expressions in the
OLETF rats compared with the LETO
rats. In addition, iNOS and
collagen expression were not changed in the
OLETF rats in spite of
alcohol consumption.
Superoxide dismutase levels, which is involved in
antioxidant defense, in the LETO
rats were significantly decreased after
alcohol consumption, however those in the
OLETF rats were
similar. Moderate
alcohol consumption reduces the
oxidative stress, and may prevent molecular and pathologic changes of the
bladder of
rats with
type 2 diabetes.