Regulation of tazarotene on HB-EGF in hyperproliferative epidermis of psoriasis / 西安交通大学学报(医学版)
Yan ZHENG; Shengshun TAN; Zhenhui PENG; Yanping XI.
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en Zh
| WPRIM | ID: wpr-540813
Objective To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods HB-EGF mRNA in active psoriatic lesions before and 10 days after the treatment with tazarotene was detected by hybridization in situ. Results There was nearly no expression of HB-EGF mRNA in psoriatic lesions (9.1%); after the treatment with tazarotene, there was expression of HB-EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%). Conclusion Tazarotene can inhibit proliferation and induce apoptosis of keratinocytes though upregulating expression of HB-EGF in psoriatic epidermis.
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WPRO
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