Reversal effects of carvedilol on multidrug resistance in bladder cell lines / 中国癌症杂志
Yuanning ZHANG; Tangjun YANG; Xiangwei WANG.
China Oncology
; (12)2001.
Artículo
en Zh
| WPRIM | ID: wpr-541108
Purpose:
To study the reversal effects on multidrug resistance in multidrug-resistent bladder cell lines BIU-87/ADM.Methods:
The degree of drug-resistence was detected by MTTmethod; the concentration of ADM in cells BIU-87 and BIU-87/ADM was detected after the cells were treated by carvedilol and ADM.Results:
Pretreatment by carvedilol increased the concentration of ADM in BIU-87/ADM cells, ,and the concentration was much higher than that in those cells treated by ADM only.Conclusions:
Carvedilol can enhance the cytotoxic effect of ADM,and can reverse the multidrug resistance in bladder cancer lines BIU-87/ADM.
Biblioteca responsable:
WPRO
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