Objective To analyze the factors that influence the
disease-free survival time after radical
prostatectomy for
prostate adenocarcinoma and to study the expression and significance of Bcl-2,C-erbB-2,Ki-67 in
prostate adenocarcinoma.
Methods A total of 51 cases of
prostate adenocarcinoma undergoing radical
prostatectomy were reviewed.Cox
proportional hazard model was used to investigate the impact and co-impacts of the factors,which included age, preoperative PSA level,Gleason scores of
biopsies and operative specimens,EPE,MR,SVI,LN,PAT,PRT and having
testes or not during follow-up.Immunohistochemical
staining was used in
biopsies and resected specimens to evaluate the positivity of Bcl-2,C-erbB-2,Ki-67 in 15 of the 51 cases. Results In stepwise
Cox proportional hazards model, the
prognostic factors for
recurrence were age(P=0.011),maximal
androgen blockade(P=0.017), positive margin of resection(P=0.000),postoperative
Gleason score(P=0.002),having
testes or not after operation(P=0.040).The expressions of 3 types of
proteins showed negative correlation with the
prognosis of
prostate carcinoma. Conclusions Among clinicopathologic factors,positive resected margin is the most powerful
prognostic factor.
Patients will benefit from maximal
androgen blockage before radical
prostatectomy.
Disease-free survival after radical
prostatectomy is not influenced by not having pelvic
lymphadenectomy after finding no enlarged
lymph nodes intraoperatively.Not preserving
testes after
prostatectomy is a favorable factor.The
prognosis of
prostate carcinoma can be predicted with the expressions of Bcl-2,C-erbB-2 and Ki-67 in
biopsies or resected specimens.