Objective To investigate the pathogenic
bacteria and
drug resistance in
orthopedics patients, so as to guide the clinical use of
antibiotics.Method708
secretions and
pus samples from orthopedic
outpatients and
inpatients were cultured aerobically.The detectable
bacteria were subjected to
drug sensitivity test
in vitro by the K-B assay.Result259 pathogenic
strains were detected, and 47.9% of them were Gram-positive (
Staphylococcus aureus, 33.0%
coagulase-negative staphylococci, 14.9%),and the remaining 52.1% were Gram-negative (
Pseudomonas, 7.3%;
Acinetobacter, 6.1%). The
drug-resistant rate of
Gram-positive cocci to
penicillin and oxcillin tended to raise over the three years however, all the detected
Gram-positive cocci were sensitive to
vancomycin (100%).Most Gram-negative bacilli were sensitive to
imipenem (95.8%) in the past three years and the
sensitivity to
ceftazidime was also high; however, the
sensitivity tended to fall over the past three years. The
drug-resistant rates of Gram-negative bacilli to CiprofIoxacin.
amikacin and
piperacillin were 46.0%. 47.0% and 51.2% respectively.ConclusionGram-negative bacilli dominate the pathogenic
bacteria in orthopaedic
patients and they tend to increase. The
incidence of
infections by
Gram-positive cocci is lower than that of
infections by Gram-negative bacilli. In terms of individual
bacteria ,
staphylococcus aureus leads among all of these pathogenic
bacteria,
Vancomycin,
Oxacillin and
Norfloxacin are preferred
drugs against
Gram-positive cocci, while
imipenem and
ceftazidime are preferred for Gram-negative bacilli.The
incidence of
infections by Gram-negative bacilli tend to raise and
drug resistance of Gram-negative bacilli becomes serioushence, it is crucialOto emphasize the
detection of infectious
bacteria and
drug sensitive test and to use
antibiotics rationally.