Effects of metformin on endocrine function of the pitutary-gonad axis in rats / 中国药理学通报
Bai KANG; Peng DUAN; Guangzhou LI; Huirong HAN.
Chinese Pharmacological Bulletin
; (12)2003.
Artículo
en Zh
| WPRIM | ID: wpr-557130
Aim To study the effects of Metformin (MF) on endocrine function of pituitary-gonad axis in rats. Methods The serum hormone concentration was measured with radioimmunoassay (RIA) and the morphology of gonad endocrine cells was observed with electron microscope. Results MF(135 mg?kg-1?d-1,ig,14 d)decreased serum T concentration in male rats and serum LH concentrations in female rats significantly(P
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