Study of realgar induced apoptosis of eosinophils from bronchoalveolar lavage fluid in asthmatic guinea pigs / 中国临床药理学与治疗学
Jide XU; Zhixiang HUANG; Shaowei YANG; Zhonghui WEN; Ruifang ZENG.
Artículo
en Zh
| WPRIM | ID: wpr-559949
AIM:
To observe the realgar induced the apoptosis of eosinophils from bronchoalveolar lavage fluid in asthmatic guinea pigs and investigate the mechanism that realgar treated asthma.METHODS:
The morphology of apoptosis of eosinophils was observed by Giemsa staining and electron microscope.The rate of apoptosis of eosinophils was assayed by the flow cytometry.RESULTS:
The characteristic changes of the apoptosis in both light microscope and electron microscope were shown after 6 hours treatment of realgar.Flow cytometry showed that the rate of apoptosis of the eosinophils was increased with both increasing realgar concentration and prolonging realgar action time to the cells.CONCLUSION:
Realgar promotes the apoptosis of eosinophils from bronchoalveolar lavage fluid in asthmatic guinea pig.Realgar induced the apoptosis of eosinophils is one of the causeses for asthmatic treatment.
Biblioteca responsable:
WPRO
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