Advances in prevention and treatment on inflammation and myocardial ischemia-reperfusion injury by PPAR-γ ligands / 中国病理生理杂志
Jingwei LIU; Ruijuan XIU.
Chinese Journal of Pathophysiology
; (12): 197-199,208, 2010.
Artículo
en Zh
| WPRIM | ID: wpr-570837
Peroxisome proliferation-activated receptor-γ (PPAR-γ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily and participates in the regulation of various metabolic pathways as well as inflammatory responses. PPAR-γ ligands significantly improve myocardial functional recovery and prevent ischemia-reperfusion induced injury. Given the increasing understanding of the cardioprotective effects of PPAR-γ ligands, we know today that the therapeutic effects of PPAR-γ ligands reach far beyond their use as insulin-sensitizers, as many of these agents exert beneficial effects in the conditions associated with ischemia-reperfusion and inflammation.
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