AIM:
To study the therapeutical effects of salvianolic
acid B (Sal B) on
myocardial infarction(MI) in
dogs.
METHODS:
The models of
myocardial infarction were produced by
ligation of the left anterior descending (LAD)
coronary artery in the anaesthetized
dogs. The extent of
myocardial ischemia was detected by epicardial-
electrocardiogram and the extent of
infarction was determhled by N-BT
staining method. The parameter of
lactate dehydrogenase was determined in the
serums of
dogs.
RESULTS:
It was indicated that the adminstration of Sal B(1、3 and 10mg/kg) by the way of
intravenous injection reduced the extent of
myocardial infarction (N-ST) ( P