A twenty-one year old man,
who had been treated for
medulloblastoma 6 years ago, complained progressive right
knee joints pain and
back pain. Multiple thoracic vertebral
compression fracture was detected in
radiography. The
bone mineral density(BMD) was in osteoporotic range in duel energy
X-ray absorpometry.
Growth hormone deficiency and
primary hypothyroidism were detected after endocrine function test. We treated him by cyclic intravenous
pamidronate because he had complained severe
back pain and difficulty to walk. After
pamidronate therapy, the
pain was decreased and the BMD was increased. No severe adverse effect was noted. This is the first case
report of
pamidronate therapy in
patient who had osteoporotic vertebral
compression fracture due to a sequela of
childhood medulloblastoma.