Auto-dendritic cell-vaccine in treatment of patients with condyloma acuminatum:a clinical study / 中国肿瘤生物治疗杂志
Xiaoqin SHI; Junquan LIU; Fuxing CHEN; Weifeng CHEN.
Chinese Journal of Cancer Biotherapy
; (6)1995.
Artículo
en Zh
| WPRIM | ID: wpr-589367
Objective:
To observe the effects of auto-dendritic cell vaccine on T cells of patients with condyloma acuminatum(CA) related human papilloma virus(HPV) and its clinical outcome.Methods:
73 patients with condyloma acuminata(CA) in the present study were positive of HPV-DNA and have been unsuccessfully treated with freezing,laser,or electric therapy combined with interferon anti-virus treatment for half a year.The peripheral blood samples were harvested from patients and the monouclear cells were extracted to cultivate DCs in presence of cytokines.Auto DCs were sensitized with corresponding HPV virus antigen of a patient to prepare the auto-dendritic cell vaccine.Then the vaccine were cultivated with auto T-cells and the proliferation of T cells were examined.Meanwhile,the auto-DC vaccine(1-4)?107 was also injected into the patients' inguinal lymph glands and its therapeutic effectiveness was observed.Results:
The prepared DC-vaccine significantly promoted the proliferation of auto T cells compared with control group(P
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