OBJECTIVE To investigate the distribution of clinical bacterial isolates and the change in
antibiotic resistance spectrum in our
hospital from 2005 to 2007.
METHODS Data of bacterial susceptibility testing of clinical isolates from the Second Affiliated
Hospital in of
University of South
China from 2005 to 2007 were collected and analyzed by
software WHONET25.Results were assessed according to the National Committee for
Clinical Laboratory Standards(NCCLS) of
America issued in 2005.RESULTS The amount of
Gram-negative bacteria decreased and of
Gram-positive bacteria increased during this period.The proportion of
coagulase negative
Staphylococcus(CNS) had been increasing and reached 21.7% in 2007.The proportions of
Staphylococcus aureus decreased from 17.6% in 2005 to 13.0% in 2007.
Escherichia were the top two
bacteria in 2007.The
drug resistance rate of staphylococci against
penicillin and
erythromycin was more than 92.2% and 52.2%,respectively.The
oxacillin resistance rate of CNS was 74.5%,significantly higher than that of S.aureus(16.5%).
Drug resistance rate of
Enterococcus to
vancomycin was 1.1%.
Gram-negative bacteria were found resistant to
meropenem and
imipenem.The resistance rate to
ampicillin of
Klebsiella and
Escherichia was very high.CONCLUSIONS The variation of
drug resistance and distribution of clinical bacterial isolates in our
hospital are related to the improper use of
antibiotics.It is very important to select
antibiotics correctly according to the results of
antibiotics susceptibility tests.