Objective To explore the application value of
Carbon Nanoparticles followed by microscale Methylthioninum
Chloride in
sentinel lymph node biopsy for
breast cancer.
Methods Two hundred and eight
breast cancer patients were selected in the First Affiliated
Hospital of Zhengzhou
University during recent two years
who performed
sentinel lymph node biopsy.They were randomly divided into five groups according to different lymphatic tracer injectedSequential group (A group,128
patients),
Carbon Nanoparticles group (B group,44
patients) and Methylthioninum
Chloride group (C group,36
patients).According to different Methylthioninum
Chloride doses,sequential groups were randomly divided into low
dose group (A1 group,48
patients),middle
dose group (A2 group,42
patients),high
dose group (A3 group,38
patients),If
sentinel lymph nodes were negative no longer performed axillary
lymph nodes dissection.Receive the five groups
statistics of
detection rate,the condition of lymphatic tracer,the
incidence of local
skin irritation and so on.Results (1) The
detection rate of A,B and C three groups had no obvious difference.The
incidence of lymphatic tracer dyed not ideal in B group was higher than A and B two groups,the
incidence of local
skin stimulation in C group was higher than A and B two groups.(2) A1,A2,A3,three groups had no difference of the
detection rate and lymphatic tracer,but the
incidence of local
skin stimulation in A3 group is higher than A1,A2 two groups.3.5 groups of SLN
detection rate had no relationship with
patients' age,BMI,
tumor size,
tumor location,
tumor molecular
classification factors (P > 0.05).Conclusions
Carbon Nanoparticles followed by microscale Methyhhioninum
Chloride detection rate was
similar with two separate application,but can reduce the
lymphatic vessels not developing situation when used
Carbon Nanoparticles alone and reduce the local irritation caused by large
dose of Methylthioninum
Chloride,so it can be a good choice of SLNB in clinical.