Thirty-three
patients with new-onset
type 1 diabetes from Zhongshan
Hospital, Fudan
University were recruited from 2013 to 2014. Relevant clinical data were collected for the
statistical analysis. Among the 33
patients with
type 1 diabetes, there were 7 with fulminant
type 1 diabetes (FT1DM), 12 acute onset
type 1 diabetes (AT1DM), and 14 with slowly progressive
type 1 diabetes (SPIDDM). The
fasting and stimulated
C-peptide levels were significantly lower while glycated
albumin (GA)/HbA1C and mean amplitude of
glucose excursions (MAGE) levels were significantly higher in FT1DM group compared with other two groups(all P<0.05). Pearson correlation
analysis in all
patients with
type 1 diabetes revealed that GA/HbA1C was correlated with
fasting C-peptide, MAGE, and difference of the peak
blood glucose to the lowest
blood glucose (ΔBG) levels (all P<0.05). Stepwise
multivariate analysis showed that GA/HbA1C was independently correlated with MAGE and ΔBG (P<0.05).
Logistic regression model indicated that GA, HbA1C, and GA/HbA1C were independently correlated with FT1DM.