Objective To investigate the
clinical efficacy of Dahuang Xiaozhi Suppository combined with
tetracycline in treating type Ⅲ
prostatitis infected with nano-
bacteria.
Methods Totally 120
patients of type Ⅲ
prostatitis infected with nano-
bacteria were randomly divided into
treatment group and
control group, with 60 cases in each group. Both groups were disabled anti-infective
drugs and other preparations for
diet and
life intervention. Both groups received
tetracycline, once a
tablet, twice a day, orally. The
treatment group received Dahuang Xiaozhi Suppository, once a
capsule, once a day, placing in the
anus 3-4 cm. 10 d was a
treatment course, for 3
courses. The
clinical efficacy, major symptoms improving
time, NIH-CPSI,
leukocyte count and ecithin corpuscles in expressed prostatic
secretion (EPS), urinary flow rate, and
cytokine content of TNF-α,
IL-6,
IL-8, were evaluated. Results The total effective rate was 100.0% (60/60) in
treatment group and 83.3% (50/60) in the
control group, and
treatment group was higher than the
control group (P<0.05).
Pelvic pain, urinary symptom, and
scrotum wet improvement
time of
treatment group were lower than the
control group (P<0.05). Compared with before the
treatment, the NIH-CPSI
pain scores, urinary symptom scores,
life quality score,
leukocyte count and TNF-α,
IL-6,
IL-8 content of EPS in both groups were significantly lower
after treatment (P<0.05), and the cases with
lecithin corpuscles +++ - ++++ in both groups significantly increased
after treatment (P<0.05). The urinary peak flow rate and mean flow rate in both groups were higher
after treatment (P<0.05). There was statistical significance in the scores of NIH-CPSI
pain, urinary symptom and
life quality,
leukocyte count and TNF-α,
IL-6,
IL-8 content of EPS, and the cases with
lecithin corpuscles ++++ between the two groups (P<0.05). Conclusion Dahuang Xiaozhi Suppository can improve the
efficacy of treating type Ⅲ
prostatitis infected with nano-
bacteria. Combining Dahuang Xiaozhi Suppository with
tetracycline can reduce
prostate inflammation, with obvious
efficacy.