Objective To provide a theoretical basis for the pulmonary enteric
therapy in treating intestinal
dysbacteriosis complicating allergic
asthma according to the traditional theory of
Lung and
Large intestine are interiorly-exteriorly.
Methods The experiment included the blank group,model group,positive
control group and three kinds of
traditional Chinese medicine compound
administration group;the intestinal
dysbacteriosis in SD
rats was duplicated by adopting
cefoperazone and
candida albicans gavage.On this basis
ovalbumin injection sensitization and nebulization were applied to induce
asthma.Meanwhile Jia-Wei-ShengJiang
Powder(SJS),Guizhi-Jia-Houpu-Xingzi Decoction(GHX) and Zeng-Ye-Cheng-
Qi Decoction(ZYCQ) were orally administered for
treatment of
lung-
intestine combine
therapy,
lung therapy and
intestine therapy.The respiratory function was analyzed by using the Buxco
whole body plethysmography.The variety of
intestinal flora were analyzed by using 16SrDNA.Results Analyzing the specieces composition of
intestinal flora in each group by the OUT value found that the recovery of
Lactobacillus in each group was close to that in the blank group and better than that in the positive group,meanwhile,3
treatment groups all could promote the recovery of
Proteobacteria and
bacteroidetes,but the
lung-
intestine combine
therapy had optimal effect,the Alpha diversity
analysis found that the
intestinal microflora diversities from high to low were in turn the intestinal
therapy group,
lung therapy group,lungintestine combined
therapy group and model group;the respiratory frequency and
airway hyperreactivity in the model group was 260.56(1.28),which in the
lung-
intestine combined
therapy group,
lung therapy and
intestine therapy after treatment were 141.79 (0.93),137.25 (1.30) and 203.16 (0.84) respectively,the
rat respiratory frequency in each
treatment group was lower than that in the model group,while the
airway hyperreactivity only in the
lung-
intestine combined
therapy group and intestinal
therapy group was lower than that in the model group,moreover showing statistical significance.Conclusion The
lung-
intestine combine
therapy method for treating
rat intestinal
dysbacteriosis complicating allergic
asthma is superior to simple
lung therapy method or
intestine therapy method.