Objective By studying clinical features,
treatment and
prognosis of eosinophilic
gastroenteritis of
infants resulted from
milk protein allergy an, to improve the
diagnosis and
treatment level of eosinophilic
gastroenteritis .
Methods 24 cases of
infants which diagnosed eosinophilic
gastroenteritis were chosen from June of 2010 to January of 2014 in
children ’s
Hospital of XX province and By retrospective
analysis clinical manifestations, endoscopic features, histopathology,
treatment and
prognosis of the 24 cases. Results The 24 cases
who were
vomiting , paroxysmal
crying , abdominal distension (100.00%), which accompanied by haematemesis 23 cases (95.83%), 1case (4.17%)
hematochezia , 17cases (70.83%)
eczema , 21 cases (87.50%) mild to moderate
anemia , 1 cases (4.17%) severe
anemia , 19 cases (79.17%) the increasing of peripheral
blood eosinophil cells , 8 cases (33.33%)the increasing of
IgE of the
serum and 4 cases (16.67%) the test of antibody of the
Helicobacter pylori in
Serum was positive; 3 cases (12.50%) were
milk protein allergy by the detecting of
food allergen -speciifc
IgE antibodies , the endoscopic characteristics were
hyperemia ,
edema ,
erosion ,
ulcer of gastric and duodenal
mucosa . Among them, 24 cases (100.00%) were
gastritis , 5 cases (20.83%)
duodenitis and 1 cases (4.17%)
duodenal ulcer . The histopathology of the 24 cases revealed that there were gastric or duodenal
eosinophils infiltration (> 20/HPF) and were all associated with
mast cell infiltration; By antisecretory,
protection of the gastrointestinal
mucosa and the obviating of
milk protein had a satisfactory
treatment effect, 24 cases of
children with oral general formula
milk test conifrmed that the
milk protein allergy , The 3 cases of the
patients were reviewed by 8~12 weeks after
gastroscope , and the
mucosa of the
duodenum was smooth,
Eosinophils were/HPF<8,
mast cells were/HPF<5. Conclusion There are no speciifc clinical and endoscopic manifestations in eosinophilic
gastroenteritis of
infants resulted from
milk protein allergy , gastrointestinal
mucosa eosinophil inifltration and simultaneously are accompanied by abnormal
mast cell inifltration;Mucosal type without the use of
corticosteroids , through
milk protein avoidance
treatment can achieve satisfactory results, But definite
diagnosis must rely on
biopsy and
eosinophils , combined with avoidance stimulation test of
milk protein can further confirmed, But the excitation test should be at least 10 days of
observation of
children , and carefully recorded symptoms, so as not to delay the
missed diagnosis of CMPA.