Does Oral Lansoprazole Really Reduce Gastric Acidity in VLBW Premature Neonates?
Tham Sock Ying; Rogers Ian M; Samuel KF; Singh A; Ong King Kok.
The Medical Journal of Malaysia
; : 284-288, 2012.
Artículo
en Inglés
| WPRIM | ID: wpr-630222
Premature neonates of very low birth weight (VLBW) whose treatment required the use of naso-gastric tube feeding were investigated. 10 infants suspected of having GERD (gastroesophageal reflux) received oral lansoprazole therapy by tube administration. 9 other infants formed a control group. In the treated group a fasting pH was determined before treatment and again after 7 days treatment. The control group was similarly assessed at an interval of 7 days. Despite acid reduction, the post-treatment pH mean of 1.31 would continue to pose a threat to the esophageal mucosa. The physiology of neonatal acid secretion is discussed to explain these findings.
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