The
association between
atrial natriuretic peptide (
ANP) polymorphism and
coronary heart disease (CHD) was studied in
Chinese population. The
genotypes of
ANP T2238C and
ANP C-664G were detected by
polymerase chain reaction and
restriction fragment length polymorphism (
PCR-
RFLP)
methods in 158 consecutive CHD
patients and 165 controls. It was found that the distribution of A2A2
genotype in CHD group was significantly higher than that in
control group (P0.05). The results suggest that A2A2 T2238C
genotype could be one of the
risk factors for CHD (P<0.05, OR 1.80, 95 % CI 1.03-3.15).