The relationship of
HLA-A, -Cw
alleles on
HIV infection and
AIDS disease progression in the
Chinese Yi
ethnic group of Sichuan province were investigated. The
genetic polymorphisms of
HLA-A, -Cw
alleles of 102 unrelated healthy
Chinese Yi ethnic individuals, 68
HIV-1 infected and 21
HIV positive long-
time survivors were typed by
PCR-SSP assay.
Statistic signifiance was determined by the χ2 test with the SPSS
software. No significant differences were observed between the
HLA-A, -Cw
alleles of the 68
HIV-1 infected and 102 non-infected
Chinese Yi control individuals. Whereas the
prevalence of A*3601,Cw*14(01-03)and Cw*0304 was significantly higher in 21 long
time survivors compared with 102 healthy controls with P values of 0.016, 0.016 and 0.000 by χ2 or the Fisher exact test respectively. The result implies that A*3601,Cw*14(01-03) and Cw*0304 may be associated with slow
AIDS disease progression in the
Chinese Yi
ethnic group, further studies on this
association may yield insight on the pathogenesis of
HIV-1 infection.