Relationship between vimentin and glucocorticoid-induced cataract / 国际眼科杂志(Guoji Yanke Zazhi)
Jia-Jia, GE; Sheng, SU; Ping, LIU.
International Eye Science
; (12): 1975-1977, 2014.
Artículo
en Zh
| WPRIM | ID: wpr-637077
Long-term use of systemic or topical glucocorticoid can cause posterior subcapsular opacities ( PSO ) , named glucocorticoid-induced cataract ( GIC ) . There are many hypotheses on the pathogenesis of GIC. However, no one has well explained the formation of PSO, which leads to no effective approaches in the prevention and/or treatment. A new opinion is that hormones might affect lens epithelial cells through GR - mediated vimentin changes, which eventually result in the formation of GIC. Therefore, the association between vimentin and lens epithelial cell proliferation and differentiation, maybe a new direction for further studies in the pathogenesis of GIC.
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