Compared with the control group,VEGF levels in serum and retina were increased significantly in the NOD group(12 weeks4.9±0.4μg/g versus 0.19±0.1μg/g in serum sample,P < 0.01;165.0±9.0μg/g versus 18.0±4.0μg/g in retinal sample,P<0.01).There exists a positive correlation between serumVEGF and retinalVEGF levels in the early diabetic NOD mice(γ=0.9902,P=0.001).The number of the cellsapoptosis in the ganglion significantly in the NOD group(P<0.01).
CONCLUSION:
The high VEGF expression may be contributed to increase retinalcellsapoptosis.Many factors associated with retinalVEGF expression might involve in the early diabetes stage.