Hydrocolloid dressings have been developed for many types of
wound healing. In particular,
dressing is a critical component in the successful recover of
burn injuries, which causes a great number of people to not only suffer from physical but also psychological and economic anguish each year. Additionally,
silk fibroin is the safest material for
tissue engineering due to biocompatibility. In this study, we fabricated
hydrocolloid dressings incorporating
silk fibroin nanoparticles to enhance the
efficacy of
hydrocolloid dressing and then use this
silk fibroin nanoparticle hydrocolloid dressing (SFNHD) in
animal models to treat
burn wounds. The structures and properties of SFNHD were characterized using
tensile strength and
Cell Counting Kit-8 assay. The results indicated the structural stability and the cellular biocompatibility of the
hydrocolloid dressing suggesting that SFNHD can be applied to the
treatment of
wounds. To demonstrate the capacity of a
silk fibroin hydrocolloid dressing to treat
burn wounds, we compared SFNHD to gauze and Neoderm®, a commercially available
dressing. This study clearly demonstrated accelerated
wound healing with greater
wound structural integrity and minimal
wound size
after treatment with SFNHD. These observations indicate that SFNHD may be an improvement upon current standard
dressings such as Gauze and Neoderm® for
burn wounds.