Distribution of Myosin Heavy Chain Isoforms in the Musculus Uvulae of Patients with Snoring and Obstructive Sleep Apnea Syndrome Using ATPase Staining Method / 대한이비인후과학회지
Thirty seven patients included in the study underwent an uvulo-palato-pharyngoplasty (UPPP). All subjects had polysomnographic study before UPPP. ATPasestain at pH 9.4 were applied to muscle specimens obtained during UPPP. The numbers of MHC type I and II isoforms were counted. The patients were divided into three groups according to their repiratory disturbance index (RDI)mild (0-20), moderate (21-40), severe (>40). The differences in the distribution of muscle fiber types were compared between these groups. The correlation between the distribution of the fibers and the body mass index / age / RDI / minimum O2 saturation / duration of sleep apnea was investigated.
RESULTS:
The mean percentages standard deviation of type I fibers according to the severity of sleep apnea were as follows22.5+/-3.2% in mild sleep apnea group (n=5), 19.8+/-2.3% in moderate sleep apnea group (n=1), 17.5+/-3.6% in severe sleep apnea group (n=1). There were statistically significant differences in the distribution of MHC type I and II isoforms between mild group and moderate and / or severe group (p.05).
CONCLUSION:
The proportion of MHC type I isoforms in musculus uvulae was decreased according to the severity and duration of sleep apnea (p<.01).