Primary
liver cancer,particularly
hepatocellular carcinoma(HCC),is a common type of digestive
tumor in
China.The majority of HCC
patients is diagnosed with advanced stage and thus cannot be treated with
surgery and local
treatment.Systemic
therapy is considered to be the main
treatment of advanced HCC.The effect of traditional cytotoxic
drug chemotherapy on advanced HCC is not evident.Although
sorafenib,a molecular-targeted
drug,has
survival benefits,this
drug is expensive and has low objective effective rate of only 2%-3%. Metronomic
chemotherapy has received increasing
attention because it targets
tumor angiogenesis for the
treatment of advanced metastatic
cancer.This article aimed to
review the progress of metronomic
chemotherapy in advanced HCC
treatment.