The color of the livertissue became lighter,and the weight and weight index were changed significantly in miR-7KD mice compared with control group (P < 0.05).HE staining showed that the inflammatory cell infiltration was increased in the liver of miR-7KD mice.Moreover,the level of serum ALT was significantly increased (P < 0.05).The serum level of IFN-γelevated significantly (P < 0.01),while the IL-4 levels decreased significantly (P < 0.01) in the serum of miR-7KD mice.Furthermore,the proportion of CD4 + T cells and relative IFN-γcells increased obviously (P < 0.01).
CONCLUSION:
miR-7 knockdown promotes the pathogenesis of the ConA-induced acute liverinjury in mice.