Biblioteca Virtual en Salud

Objective:

To explore the impact and curative effect of radiofrequency ablation (RFA), laparoscopic surgery and total hysterectomy for ovarian function in the treatment of uterine fibroids.

Methods:

60 patients with uterine fibroids were divided into RFA group (20 cases) and laparoscope group (20 cases) and panhysterectomy group (20 cases) as different therapeutic method. The serum follicle stimulating hormone (FSH) and estradiol (E2) of three groups in preoperative, postoperative 3th month and postoperative 6th month were detected, respectively. The influence and curative effect of different therapeutic method on ovarian function were compared and analyzed.

Results:

All of operations of three groups were successful at the first time, and the total effective rate of the three groups were 98% (19/20), 98% (19/20), 100% (20/20) at postoperative 3th months, respectively. And the total effective rate of the three groups were 90% (18/20), 98% (19/20), 100% (20/20) at postoperative 6th months, respectively. There was no significant difference between the 3th month and 6th month (F=5.350,F=8.319,P>0.05). The hormonal level of patients in three groups were abnormal at preoperative period, while at postoperative 3th month, the normal hormonal levels were, respectively, 60% (12/20) in RFA group, 50%(10/20) in laparoscope group. And the differences of each group between pre and post operation were significantly (t=7.938,t=8.362,P<0.05), respectively. And at the postoperative 3th month, the serum FSH and E2 of pan-hysterectomy group were no, respectively, significant higher and lower than that of preoperative results (t=2.017,P>0.05). At the postoperative 6th month, the normal hormonal level were, respectively, 70% (14/20) in RFA group, 65% (13/20) in laparoscope group. And the FSH and E2 of these groups were significantly higher and lower than that of pre-operation (t=10.918, t=11.218,P<0.05).

Conclusion:

All of the three methods has significant curative effect in the treatment of uterine fibroids, and the ovarian function is improved by using RFA and laparoscope while it is recession by using pan-hysterectomy.