Objective Discuss the
clinical efficacy of
caffeine citrate and
aminophylline in
treatment of primary
apnea of prematurity.
Methods 80 cases of primary
apnea of prematurity were selected.They were divided into two groups randomly.The
control group (40 cases) received
aminophylline treatment and the
observation group (40 cases) received
caffeine citrate therapy.The
efficacy of
caffeine citrate and
aminophylline in
treatment of primary
apnea ofprematudty was evaluated by
efficacy,primary
apnea episodes and disappeared
time,adverse reaction during
treatment.Results The effective rate of
observation group was 85%,the effective rate of
control group was 75%.The
observation group had higher
efficiency (P < 0.05).The frequency of
apnea of
observation group was less than that of the
control group.The disappearance
time of
observation group was shorter than that of the
control group (P < 0.05).During the
treatment,the
tachycardia,
feeding intolerance,
bronchopulmonary dysplasia and other adverse reactions rate of
observation group was lower than that of the
control group (P < 0.05).Conclusion Compared with
aminophylline,
caffeine citrate had a good
therapeutic effect of primary
apnea of prematurity.It can reduce
apnea frequency,eliminate clinical symptoms with high
safety.It was an ideal
drug for
treatment of primary
apnea.