Autoimmune
thyroid disease (AITD) is an archetypal organ-specific autoimmune disorder that is characterized by the
production of
thyroid autoantibodies and lymphocytic infiltration into the
thyroid.Excessive
iodine can increase the
incidence of AITD.During
trapping,
oxidation and organification of excessive
iodine in
thyroid cells,excessive
reactive oxygen species (ROS) were generated,which induces
apoptosis of
thyroid cells,accelerates
thyroglobulin autoantigen presentation,promotes
lymphocytes infiltration and
cytokine expression.Excessive
iodine is an
environmental risk factor which promotes the people with stealth autoimmune
thyroid disease to get sick.In this article,we discussed the relationship between excessive
iodine and AITD and its mechanism.