Objective To investigate
platelet function with special regard to the
role of
platelet membrane glycoproteins (GPIIb/IIIa?GPIb) and
endothelial cell disturbance in the older non valve cardiac
patients with
atrial fibrillation and their clinical implications.
Methods 22 older
patients with non valve cardiac
atrial fibrillation were studied. There were two age and
sex matched
control groups, one with 18
patients in sinus rhythm with
cardiovascular disease, called the normal sinus rhythm group; the other with 16
health subjects named the
health control group. The expression of activated GPIIb/IIIa and GPIb on
platelet was analyzed with
flow cytometry.
Mean platelet volume (MPV) was measured by automatic hematologic analyzer, the
plasma vWF was assayed using
ELISA. Results The non valve
atrial fibrillation group had markedly activated
platelet, indicated by increased expression of activated GPIIb/IIIa ( P