IgA and Differentiation-associated Transcription Factors in Chronic Otitis Media with Effusion
Il-Ho SHIN; Ok-Young SHIN; Sung-Ho CHA; Young-Il KIM; Jin-Woo LEE; Seung-Geun YEO.
Clinical and Experimental Otorhinolaryngology
; : 131-135, 2009.
Artículo
en Inglés
| WPRIM | ID: wpr-68330
OBJECTIVES:
Inadequate antibody responses to pathogens may lead to the recurrence of otitis media with effusion (OME). Although B-cell production by antibodies is controlled by transcription factors, the status of these factors has not been assessed in patients with OME.METHODS:
Expression of immunoglobulin was measured by enzyme-linked immunosorbent assay. Expression of transcription factors Bcl-6, Blimp-1, Pax-5, and XBP-1 was assessed by RT-PCR in the middle-ear fluid of 29 children with >4 OME episodes in 12 months or >3 episodes in 6 months (the OME-prone group) and in 32 children with 0.05).CONCLUSION:
Lower concentrations of IgA, Blimp-1 and XBP-1 in middle ear fluid of patients with OME may be related to OME recurrence and chronicity.
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WPRO
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