To improve the
antibiotics production of
Streptomyces qinlingensis sp. nov.,
protoplast regeneration combined with physical and chemical
mutagenesis was used to selected high-yielding
strains. The results showed that the antibacterial activities of
strain R-72 from
protoplast regeneration and NTG-1,H30-7 from
protoplast mutagenesis against
Bacillus subtilis were more than 20% higher than that of the original
strain,and the
heredity characters of those
strains were stable in successive ten
generations. The further
bioassay experiments exhibited that the fungicidal and antibacterial activities of the
fermentation broth from R-72,NTG-1 and H30-7 were remarkable increased comparing with that of the starting
strain.