To evaluate the effect and mechanism of aerial parts of
Salvia miltiorrhiza (SM) on high
sugar -induced
Drosophila melanogaster metabolic disorder model. The levels of
glucose ,
triglyceride and
protein in SM were detected; nymphosis
time was recorded, and the reliability of metabolic disorder model as well as the mechanism of aerial parts of SM were evaluated based on
metabonomics . The results showed that the levels of
glucose and
triglyceride in model group were significantly higher than those in normal
control group (<0.05). As compared with the model group, the
glucose level was significantly decreased in
gliclazide (GLZ) group, SM medium(SM-M) and high(SM-H)
dose groups(<0.05, <0.01); the
triglyceride level was significantly decreased in GLZ group and SM-H group(<0.05, <0.01). By
principal component analysis (
PCA ) and partial
least squares discriminant analysis (PLS-DA), the metabolic level of model ones was recovered to a certain degree after intervention by aerial parts of SM. Seventeen marker compounds and four major
metabolic pathways were obtained by
screening differential metabolites, comparing
literature and retrieving the database. The aerial parts of SM may regulate
glycolipid metabolism through the impact on
histidine metabolism ,
glycerophospholipid metabolism ,
pentose and
glucuronate interconversions,
cysteine and
methionine metabolism and glycerolipid
metabolism . Extract from aerial parts of SM can regulate the
glycolipid metabolism of
D. melanogaster metabolic disorder model and make it return to normal condition. This
paper provides reference for the value discovery and
resource utilization of the aerial parts of S. miltiorrhiza.