Haplotype is the combination of a series of genetic
mutations that coexist on a single
chromosome, each of which has its own unique
haplotypes. As a common
data analysis method, the
analysis of
haplotype is effective for the
localization of heterozygosis
SNPs on single
chromosome, the excavation of
disease genes and the search of maladies
treatments. It mainly includes indirect computational inferential
method and direct experimental
method. In this
review we introduced various
haplotype analysis methods and applications, especially two important ones single-molecule
dilution and contiguity-preserving transposition sequencing common
technology. Meanwhile, further
research prospects on
haplotype sequencing were proposed.