Treatment of large
bone defects caused by
trauma,
osteomyelitis, and
tumors has been a major challenge in clinical. In the past, there have been many ways to repair and reconstruct the large
bone defects. However, there is a long period of
treatment, high technical requirement and
complications such as ununion. After Masquelet reported the induced
membrane technology in 2000, the
technique was widely used in
treatment of
trauma,
osteomyelitis, and large
bone defects caused by
tumors. It has been obtained good results. It has the advantages of short
course, high healing rate, easy operation and easy to master. The induced
membrane has unique structural characteristics and
biological characteristics. There are many kinds of osteogenic factors that are included in the
membrane, such as
vascular endothelial growth factor, and morphogenetic
protein-2,
transforming growth factor-β1, etc. These osteogenic factors contribute to accelerate
bone healing. With the development of induced
membrane technology. The
technology of Reamer Irrigator Aspirator
technology,
engineering tissue technology and internal fixation is used in clinic.It can provide
bone source, promote
bone defect reconstruction, improve long-term
limb function and reduce
complications.This
paper retrospectively summarizes the experimental
research and clinical progress of Masquelet
technique in the
treatment of large
bone defects.