Objective To investigate the expression of NF-κB and MTA2 in infiltrating
ductal carcinoma of
breast and their correlations to clinicopathologic
character.
Methods The expressions of and MTA2 in
breast cancer and paired adjacent normal
breast tissues of 68
breast invasive ductal
cancer patients were detected by real-
time quantitative
PCR method,and their correlations to the clinicopathologic characteristics of
breast invasive ductal
cancer were analyzed.Results The expressions of NF-κB and MTA2 in
breast invasive
ductal carcinoma were not related to age,
tumor size and histological stage (P>0.05),and were positively correlated with
lymph node metastasis and TNM stage (P<0.05).In addition,MTA2 was highly expressed in the
tissues of ER positive
breast invasive ductal
cancer patients (P<0.05).There was a positive correlation between the expression of NF-κB and the expression of MTA2 in
breast cancer tissue of the infiltrating
ductal carcinoma of
breast patients(r=0.808,P=0.012).Conclusion Measurement of NF-κB and MTA2 from
breast invasive
ductal carcinoma tissue may provide a theoretical basis for the
diagnosis,progression and
prognosis of infiltrating
ductal carcinoma of
breast.