AIM: To investigate the
clinical efficacy of
intravitreal injection of Conbercept combined with
trabeculectomy and panretinal
photocoagulation for the
treatment of
neovascular glaucoma (NVG).
METHODS: The clinical data of 90
patients with NVG treated in our
hospital from June 2014 to June 2016 were analyzed retrospectively. There were 42
patients treated with
trabeculectomy and panretinal
photocoagulation enrolled as the
control group . On the basis of this, 48
patients who received
intravitreal injection of conbercept 5-7d preoperatively were enrolled as
observation group. The best corrected
visual acuity (standard logarithmic
visual acuity ),
intraocular pressure and the regression of neovascularization were observed and compared before
treatment ,and 1wk,1,3,and 6mo post
treatment . Then the
clinical efficacy and
postoperative complications were observed and recorded.
RESULTS: The difference of
visual acuity of the two groups was significant before and
after treatment ,and the best corrected
visual acuity of
observation group was significantly higher than that of the
control group at 1mo after the operation (P<0.05), no difference was found at 1wk,3 and 6mo post
treatment (P>0.05). The pre- and postoperative
intraocular pressure of the two groups showed significant difference, and the
intraocular pressure of the
observation group was significantly lower than the
control group at 1wk, 1, 3 and 6mo post
treatment (P<0. 05). The
cure rate in the
observation group was significantly higher than that in the
control group (77% vs 64%), with statistical significance (P<0 05). The
incidence of
anterior chamber hemorrhage and shallow
anterior chamber in the
observation group was significantly lower than that of the
control group (P<0.05), with no difference in the
incidence of
macular degeneration (P>0.05). Moreover, the
recurrence rate of neovascularization in the
observation group was significantly lower than that of the
control group at 6mo after operation (P<0.05).
CONCLUSION: The
intravitreal injection of conbercept 5-7d before panretinal
photocoagulation can significantly reduce
intraocular pressure ,improve the
visual acuity for the
treatment of NVG, which also has a higher comprehensive
cure rate.