Role of SUMO-specific proteases in tumor biological behavior / 上海交通大学学报（医学版）
Hui-Xian MIAO; Zi-Hao LIU; Wei-Ya LI; Da HUANG; Wen-Bo LI; Yong ZUO.
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 348-352, 2018.
Artículo
en Zh
| WPRIM | ID: wpr-695668
SUMOylation is a dynamically reversible process that needs to be modified by a specific ligase, while its inverse reaction deSUMOylation is catalyzed by a group of SUMO-specific proteases (SENPs). SUMO-modified target protein molecules are closely related to development and disease, especially tumor, metabolism, inflammation and immunity. SENPs play an important role in SUMO protein maturation and deSUMOylation. This review discussed the functions of SENPs in the development and progression of tumors and related mechanisms.
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