Objective To study the polymorphism of
vascular endothelial growth factor (
VEGF)
gene-460T >C locus and its correlation with
bronchopulmonary dysplasia ( BPD ) in
preterm infants.
Method From October 2014 to October 2017, a
prospective study was conducted on BPD
preterm infants admitted to the neonatal department of the Affiliated
Hospital of
Inner Mongolia Medical
University .During the same
time, non-BPD
preterm infants of the same nation and same
ethnic group were selected as the
control group.The ratio between the BPD group and the
control group was 1∶1.
Genotype and allelic distribution of
VEGF-460T>C loci in both groups were detected using
polymerase chain reaction method . Result A total of 100 BPD
infants were enrolled in the BPD group , including 50 cases of Mongolian
nationality and 50 cases of Han
nationality.Both TT and CT
genotypes were detected in the
VEGF -460T>C locus in the BPD and
control groups .The frequencies of the two
genotypes were 38.0%and 62.0%in the BPD group, 29.0% and 71.0% in the
control group.The C
allele frequencies were 31.0% in the BPD group and 35.5%in the
control group.The T
allele frequencies were 69.0%in the BPD group and 64.5%in the
control group.No significant differences existed in
allele and
genotype frequencies between the two groups (P=0.178 and 0.338).The frequencies of the two
genotypes in the Mongolian BPD
infants and the Han BPD
infants were 40.0%and 60.0%vs.36.0%and 64.0%.The C
allele frequencies were 30.0%and 32.0%, and the T
allele frequencies were 70.0% and 68.0%.No significant differences existed in
allele and
genotype frequencies between the two groups ( P =0.680 and 0.648 ) .Conclusion No correlation existed between the polymorphism of
VEGF -460T>C locus and the occurrence and development of BPD in
premature infants in
Inner Mongolia.