Objective To investigate the application of modified negative
pressure closure
drainage in early stage of
snakebite .
Methods 60
patients with early
bite ulcer were selected as study objects ,and they were randomly divided into two groups according to the digital table .30
patients in the
observation group received
vacuum sealing
drainage(VSD) combined with
chymotrypsin continuous rinsing
treatment .30
patients in the
control group were given conventional
dressing bandaging
treatment .The two stage
skin grafting time,
wound healing time,
complications,disa-bility rate,
hospitalization time and
C reactive protein ( CRP) levels of the two groups were observed .And the
treatment effect was analyzed .Results The
incidence rates of
complications and disability in the
observation group were 0.00%and 3.33%,respectively,which were significantly lower than 16.67%and 26.67%in the
control group ,and the differences between the two groups were statistically significant (χ2 =4.356,6.405,all P<0.05).The CRP levels of 3 d and 7 d in the
observation group were (15.8 ±1.7)mg/L,(6.9 ±1.6)mg/L,respectively,which in the
control group were (18.6 ±2.3) mg/L,(13.8 ±1.9) mg/L,respectively,there were statistically significant differences between two groups(t=5.362,15.214,all P<0.01).The two stage
skin grafting,
wound healing,
hospital stay of the
observation group were (9.5 ±1.8) d,(24 ±1.8) d,(25.3 ±1.9) d,respectively,which were significantly shorter than those of the
control group [(16.2 ±2.6)d,(32.0 ±3.2)d,(33.2 ±3.7)d],the differences were statistically significant(t=11.604,11.93410.403,all P<0.01).Conclusion For
patients with
injury of
cobra bite to early
ulcer,using VSD
technology combined with
chymotrypsin continuous irrigation ,can significantly reduce the level of CRP and the occurrence of
complications and disability rate ,shorten the
time of two stage
skin grafting ,
wound healing time,
hospitalization time,reduce the
pain of
patients,it is the best
treatment to accelerate recovery .