Objective To compare the
efficacy of
heparin and bivalirudin in
patients with
acute coronary syndrome undergoing
emergency percutaneous coronary intervention ( PCI ) .
Methods A total of 90
patients with
acute coronary syndrome were included in this study .They were divided into the study group and
control group according to the requirements of random envelope
method ,45 cases in each group .The study group received bivalirudin during PCI,the
control group was given
heparin .The Fbg,APTT,TT and PT were detected in the two groups ,and the inci-dence of adverse reactions (
heart failure ,
cardiac death ,
platelet reduction ,
hemorrhage of
digestive tract ) was analyzed.Results
After treatment,there were no statistically significant differences between the two groups in various
blood coagulation indicators (all P>0.05).The
incidence rate of adverse events of the study group was 4.44%, which was significantly lower than 24.44%of the
control group ,and the difference was statistically significant (χ2 =7.28,P<0.05).Conclusion Application of
heparin and bivalirudin in PCI has
similar efficacy ,but the
safety of bivalirudin is higher ,which is worthy of clinical promotion .