Objective To explore the application effect of
growth hormone in
patients ≥35 years old with diminished
ovarian reserve (DOR),and to analyze
pregnancy outcome.
Methods A total of 120 cases with diminished
ovarian reserve (≥35 years old) in our
hospital were randomly divided into
observation group and
control group,each group of 60 cases.The
control group was given conventional
treatment,while the
observation group added
growth hormone.Changes of follicle stimulatng homone (FSH) and
luteinizing hormone (LH),FSH/LH,
serum estradiol (E2) level were compared between the two groups before and
after treatment,along with the
pregnancy outcome of two groups such as normal
fertilization rate,excellent
embryo rate,quantity of
egg,cleavage rate,cycle cancellation rate.Results
After treatment,the FSH and FSH/LH of the
observation group were significantly lower than those of the
control group,the
serum E2 was significantly higher than that of the
control group (P < 0.05);the normal
fertilization rate,cleavage rate and excellent
embryo rate in the
observation group were 53.96%,86.67% and 35.38% respectively,which were significantly higher than those of 33.58%,71.11% and 15.63% in the
control group (P < 0.05);the cycle cancellation rate of the
observation group was 6.67%,which was significantly lower than that of 21.67% in the
control group (P < 0.05);the biochemical
pregnancy rate and clinical
pregnancy rate of the
observation group were 38.33% and 28.33%,which were significantly higher than those of 20% and 13.33% in the
control group (P < O.05).Conclusions Diminished
ovarian reserve in
patients ≥35 years old with
growth hormone therapy,can promote the improvement of ovarian function,the biochemical
pregnancy rate and clinical
pregnancy rate,it is worthy of clinical promotion.