Objective To investigate the occurrence of common symptoms in
breast cancer patients in different
chemotherapy periods and to analyze the relationship with the
chemotherapy periods.
Methods A total of four hundred and fifty?six
breast cancer patients receiving
chemotherapy in Tangshan
Cancer Hospital from August 2016 to August 2017 were investigated via common symptom
questionnaire among
breast cancer patients. The results of the investigation were statistically analyzed, and the relationship between
chemotherapy related symptoms and
chemotherapy periods was analyzed by multiple
Logistic regression analysis. Results In terms of the 20 kinds of
chemotherapy symptoms, among the
patients whose
incidence rate was >50% had 9 kinds of symptoms. Multivariate
Logistic regression analysis showed that
alopecia (95% CI=5. 820~562. 784,P=0. 001) ,
skin allergy ( 95% CI=0. 002~0. 157,P<0. 001) ,
cancer caused
insomnia( 95% CI=1. 179~25. 638, P=0. 030) ,dry
mouth ( 95% CI=0. 008~0. 470,P=0. 007) ,vaginal
dryness or burning
heat ( 95% CI=13. 368~647. 615 P<0. 001) ,
oral ulcer ( 95%CI=0. 026~0. 654,P=0. 013) ,abnormal
defecation ( 95% CI=0. 025~0. 749,P=0. 022),
memory loss (95%CI=1. 065~19. 415,P=0. 041),distal phalanges
numbness (95% CI=0. 004~0. 421,P=0. 007),poor
appetite (95% CI=1. 189~65. 964,P=0. 033),local
skin irritation /ulceration ( 95% CI=0. 003~0. 143, P<0. 001 ) were associated with the
chemotherapy, the difference was statistically significant. The above symptoms can be divided into 3 symptom groups by
factor analysis,and they were respectively
medicine side effect
symptom cluster, neuropsychiatric
symptom cluster and mucocutaneous
symptom cluster. Conclusion There are many
symptom clusters that
affect the
life and
rehabilitation level in
patients with
breast cancer during
chemotherapy, and are closely related with the chemotherap cycle. Doctors should adopt a scientific model of symptom management and take
measures to improve the
survival state of the
patients.