Objective To evaluate the
effectiveness of
carboprost methylate suppository for
cervical ripening before diagnostic
hysteroscopy in premenopausal
women.
Methods From July 2014 to July 2015, 1614
women who were undergone diagnostic
hysteroscopy in 12
hospitals were randomly assigned into study group(n=1209)and
control group(n=405). The cases in study group were given 1 mg
carboprost methylate suppository in
vagina before
hysteroscopy, the cases in
control group were given 1 mg placebo. The extent of
cervical ripening, the
time of dilated
cervix,
pain scoring,
incidence of
drug side reactions after 24, 48, 72 hours,
satisfaction degree of
operators and
patients, the
time of
hysteroscopy,
incidence of
complications between the two groups were observed and compared. Results (1) Mean cervical widths in the study and
control groups were 6.11 ± 1.11 and 5.95 ± 1.11, and showed a significant difference(P=0.034);the percentage of
women requiring
cervical dilatation in study group was lower than the percentage in
control group significantly [28.3%(342/1209)versus 34.6%(140/405), P=0.020].(2) The
time of dilated
cervix in study group was shorter than the
time in
control group significantly [(34 ± 25) versus(52 ± 49)s, P=0.028] for the
patients whose mean cervical widths≤4.(3)There was no significant difference in
pain scores between the two groups(P>0.05).(4)The
incidence of side reactions 24, 48, 72 hours after operation were no significant difference between the two groups (P>0.05). (5) The
satisfaction degree of
operators and
patients, the
time of
hysteroscopy,
incidence of
complications between the two groups were no singnifcant difference between the two groups (all P>0.05). Conclusion Application of
carboprost methylate suppository by
vagina before
hysteroscopy is an effective and safe
method of
cervical ripening.