Objective To evaluate the prognostic value of
prognostic nutritional index (PNI) in
gastric cancer patients with peritoneal
metastasis.
Methods 287
gastric cancer patients with peritoneal
metastasis were enrolled from Jan 2010 to Dec 2016.Results Compared with PNI > 45,
patients in PNI≤45 group were elder [(59 ± 11) vs.(54 ± 11),t =3.734,P =0.000],lower
albumin [(35 ± 4) g/L vs.(42 ± 4)g/L,t =15.988,P =0.003)],lower plasm
hemoglobin concentration [(110 ± 22)g/L vs.(129 ±24) g/L,t =6.245,P =0.000),higher
platelet count/
lymphocyte count ratio [PLR,(210 ± 89) vs.(150 ± 66),t =6.547,P =0.000],higher
neutrophil count/
lymphocyte count ratio [NLR,(3.7 ± 2.9)vs.(2.4 ± 1.2),t =4.628,P =0.000],lower percentage of pallative
gastrectomy (45.5% to 58.5%,x2 =4.45,P =0.035).
Logistic regression analysis showed that age > 58-years,NLR > 2.87,PLR > 170,
hemoglobin ≤ 130 g/L,local organ infiltration were
risk factors leading to low-PNI (all P < 0.05).The median
survival time for all
patients was 8.7 months.Univariate
analysis revealed that,PNI > 45,
serum albumin > 40 g/L,no
ascites,lower-grade of peritoneal
metastasis,pallative
gastrectomy,postoperation
chemotherapy were positively associated with better
prognosis (all P < 0.05).
Multivariate analysis demonstarted that,PNI (HR =0.717,P =0.039).Grade of peritoneal
metastasis (HR =1.206,P =0.044),pallative
gastrectomy (HR =1.529,P =0.001) were independent prognostic
risk factors for the
patients with peritoneal
metastasis.Conclusion PNI are both predictors of
nutrition assessment and of
prognosis for
gastric cancer patients with peritoneal
metastasis.