Influenza vaccination is the most effective means to prevent and control
influenza epi-demics, and the
universal influenza vaccine which can induce broad and long-term protective effect is still in its infancy. Up to date, several
broad neutralizing antibodies that can antagonize a variety of influenza A vi-ruses have been identified, and the crystal structure of the antibody and HA complex reveals at least three highly conserved
epitopes. Deep insights into the molecular mechanism of the interactions between neutrali-zing
antibodies and
virus antigen can elicit a new strategy not only for rational design of
universal influenza vaccines, but also for the development of antibody-based
therapeutics against
influenza virus. In this
paper, advances in
research of universal
neutralizing antibodies and
vaccines for
Influenza A virus are reviewed.