BACKGROUND:
Pancreatic cancer is among the most common
malignancies associated with
venous thromboembolism (VTE).
Asian patients are known to have a lower
incidence of VTE compared to Caucasian
patients. However, few studies have investigated the
incidence of VTE in
Asian patients with
pancreatic cancer.
METHODS:
This retrospective
review of
medical records was performed on 505
patients with histopathologically proven advanced stage
pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang
University Hospitals.
RESULTS:
Ninety-four
patients (18.6%) had at least one
pulmonary embolism (PE),
deep vein thrombosis (DVT), or splanchnic
vein thrombosis (SVT); 38
patients had isolated SVT; and 56
patients (11.1%) had at least one classic VTE (PE and/or DVT of
lower extremities).
Patients with more advanced stages of
pancreatic cancer (distant metastatic stage,
recurrence) or
who had received
chemotherapy had a higher
incidence of classic VTE.
Patients who were simultaneously diagnosed with
pancreatic cancer and classic VTE had a poorer
prognosis than
patients with subsequent VTEs. There was a significant difference in overall
survival (OS) between the presence and absence of a concurrent classic VTE
diagnosis (median OS, 2.1 mo vs. 10.7 mo; P < 0.001). Even when VTE included SVT, the result was
similar (P < 0.001).
CONCLUSION:
In Korean
patients with advanced
pancreatic cancer, the
incidence of VTEs is comparable to that of Caucasian
patients. We also found that
pancreatic cancer patients with concurrent VTEs had a poor
prognosis compared to
patients who developed VTEs later.