Disseminated
adenovirus infection can result in high
mortality and
morbidity in
immunocompromised patients. Here, we
report the case of a 10-year-old renal
allograft recipient
who presented with
hematuria and
dysuria.
Adenovirus was isolated from his
urine. His urinary symptoms decreased after intravenous hydration and reduction of
immunosuppressants. However, 2 weeks later he presented with general weakness and
laboratory tests indicated
renal failure necessitating
emergency hemodialysis.
Adenovirus was detected in his
sputum; therefore, intravenous
ganciclovir and
immunoglobulin therapy were initiated. Renal
biopsy revealed diffuse necrotizing granulomatous
tubulointerstitial nephritis compatible with renal involvement of the
viral infection.
Adenovirus was detected in his
serum. Despite
cidofovir administration for 2 weeks,
adenovirus was also detected in the
cerebrospinal fluid, resulting in generalized tonic-clonic seizure. The
patient died 7 weeks after the onset of urinary symptoms.
Adenovirus should be considered in
screening tests for post-
renal transplantation patients who present with
hemorrhagic cystitis.