The advent of novel, direct-acting
antiviral (DAA) regimens for
hepatitis C virus (HCV)
infection has revolutionized its
treatment by producing a
sustained virologic response of more than 95% with few side effects and no comorbidities in the general
population. Until recently, ideal DAA regimens have not been available to
patients with severe renal impairment and
end-stage renal disease because there are limited data on the
pharmacokinetics,
safety, and
efficacy of
treatment in this unique
population. In a
hemodialysis context, identifying
patients in need of
treatment and preventing HCV
transmission may also be a matter of concern. Recently published studies suggest that a combination of paritaprevir/
ritonavir/ombitasvir and dasabuvir, elbasvir/grazoprevir, or glecaprevir/pibrentasvir successfully treats HCV
infection in
chronic kidney disease stage 4 or 5
patients with or without
hemodialysis.