Osteosclerotic myeloma is a rare entity, characterized by single or multiple osteosclerotic
bone lesions and usually accompanied by a
polyneuropathy syndrome (POEMS).
Multiple myeloma with osteosclerotic lesions without
polyneuropathy is exceedingly rare. We
report a case of
multiple myeloma associated with multifocal osteosclerotic lesions without any evidence of POEMS. A 48-year-old
woman presented with incidentally found
osteosclerosis of 8th thoracic
vertebra on a plain
chest film.
Bone survey, CT scan, MR scan, and
radioisotope scintigraphy revealed multiple localized osteoclerosis;
serum protein immunofixation showed
IgG, lambda
monoclonal gammopathy. A
biopsy of T8
vertebral body disclosed
plasma cell myeloma. Given that there was no organ or
tissue damage other than multifocal
osteosclerosis, the
patient was placed on close
observation with regular examination. This case indicates that although rare,
multiple myeloma should be included in the
differential diagnosis of sclerotic
bone lesions.